A free lignocaine index as a guide to unbound drug concentration.
نویسندگان
چکیده
منابع مشابه
Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active efflux by transporters, such as P-glycoprotein (P-gp), at the blood-brain barrier, the C(CSF) overestimates the corresponding C(u,brain). To ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1985
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1985.tb05132.x